Myostatin Inhibitors

Myostatin Inhibitors

What is it?

Myostatin is a member of a superfamily of related compounds known as  “transforming growth factors beta.” They are intimately related to tissue growth and differentiation, as well as many other functions. What scientists discovered was by knocking out the gene that codes for myostatin (the famed “myostatin gene”), animals would grow up hugely muscular. One needs only to see pictures of that ridiculously muscular mouse in the ads to know what I mean.

What is it supposed to do?

Scientists have been looking at these growth factors, what regulates them, what genes code for them, etc. since it may have applications to grow live-stock with greater amounts of meat and less fat, or combating wasting syndromes in humans, such as AIDS, cancer, and muscular dystrophy. For example, high levels of myostatin  have been associated with muscle wasting in HIV-infected men compared to healthy normal men. However, this simple association does not in anyway prove  myostatin directly contributes to muscle wasting, per se. It may simply be an intermediate indicator vs. a direct cause.

Relating to bodybuilders and other athletes, one theory is that the reason some people put on muscle so much easier than others is that they have a genetic propensity for making less myostatin due to a mutation in the gene. Conversely, the reason some people find it almost impossible to add muscle might be that they are genetically set up to have high levels of myostatin and, therefore, their efforts in the gym are being blocked.

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GABA

GABA

What is it?

Gamma-aminobutyric acid (GABA) is primary inhibitory neurotransmitter found in the brain and is produced from glutamate and vitamin B6, via the enzymes L-glutamic acid decarboxylase and pyridoxal phosphate. There are neurotransmitters that cause excitation in the brain and there are neurotransmitters that have the opposite effect. The balance between excitatory and inhibitory neurotransmitters is essential to proper brain function and has direct effects on all facets of human physiology, mood, health, and well-being.

What is it supposed to do?

Because GABA is an inhibitory neurotransmitter, it’s associated with inducing relaxation, reducing stress, and as a sleep aid. For example, drugs in benzodiazepine family (e.g., zanex, etc) have been shown to induce relaxation by stimulating GABA receptors, and hence induce relaxation. There’s a long list of drugs that work by interacting with GABA receptors (GABA receptor agonists) or act by increasing levels of GABA in the brain, with varying effects.

This is an extremely simplified explanation for an incredibly complex –and not fully understood – system, but it will have to suffice for this section.

As a supplement, GABA has a reputation for improving sleep and causing mild relaxation. Particular to the interests of bodybuilders and other athletes, GABA has been sold as a growth hormone (GH) releaser due to GABA’s known role as a modulator of GH release.

For more detailed information, including effectiveness, dosages, possible side effects as well as independent science based reviews of over 60 weight loss ingredients we recommend the well respected Will Brink’s supplement review module found in his complete BodyBuilding Revealed program.

Visit this site for further details:

www.Bodybuildingrevealed.com/ingredients