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Myostatin Inhibitors

February 19, 2009 by About Supplements  
Filed under Body Building Supplements

Myostatin Inhibitors

What is it?

Myostatin is a member of a superfamily of related compounds known as  “transforming growth factors beta.” They are intimately related to tissue growth and differentiation, as well as many other functions. What scientists discovered was by knocking out the gene that codes for myostatin (the famed “myostatin gene”), animals would grow up hugely muscular. One needs only to see pictures of that ridiculously muscular mouse in the ads to know what I mean.

What is it supposed to do?

Scientists have been looking at these growth factors, what regulates them, what genes code for them, etc. since it may have applications to grow live-stock with greater amounts of meat and less fat, or combating wasting syndromes in humans, such as AIDS, cancer, and muscular dystrophy. For example, high levels of myostatin  have been associated with muscle wasting in HIV-infected men compared to healthy normal men. However, this simple association does not in anyway prove  myostatin directly contributes to muscle wasting, per se. It may simply be an intermediate indicator vs. a direct cause.

Relating to bodybuilders and other athletes, one theory is that the reason some people put on muscle so much easier than others is that they have a genetic propensity for making less myostatin due to a mutation in the gene. Conversely, the reason some people find it almost impossible to add muscle might be that they are genetically set up to have high levels of myostatin and, therefore, their efforts in the gym are being blocked.

For more detailed information, including effectiveness, dosages, possible side effects as well as independent science based reviews of over 60  ingredients for gaining muscle mass we recommend the well respected Will Brink’s supplement review module found in his complete BodyBuilding Revealed program.

Visit this site for further details:

www.Bodybuildingrevealed.com/ingredients

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HMB

February 19, 2009 by About Supplements  
Filed under Body Building Supplements

HMB

What is it?

HMB is actually a metabolite of the amino acid L-leucine. L-leucine is one of three amino acids known as the branched chain amino acids or BCAA (isoleucine and valine being the other two).

It has been known for a long time that BCAA play a critical role in the turn over of lean body tissues (muscle) and is muscle sparing (i.e. anti-catabolic) in a variety of muscle wasting states. Of the three BCAA, L-leucine appears to be the most important to preserving hard earned muscle mass and intense exercise and certain disease states have been shown to eat up a great deal of L-leucine. So far so good!

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Glutamine

February 19, 2009 by About Supplements  
Filed under Body Building Supplements

Glutamine

What is it?

The ‘non-essential’ amino acid glutamine has been getting a great deal of attention over the past few years in sport nutrition publications and scientific journals and for good reason. Though it might not be considered “essential,” glutamine appears to have many potential benefits for people interested in gaining new muscle and/or preserving that hard earned muscle.

What is it supposed to do?

Glutamine is required for countless functions in the human body from immune system function, to liver function, to gastrointestinal integrity, to name only a few. Supplement companies have taken to adding glutamine to various products and athletes have taken to adding glutamine to their diet.

For more detailed information, including effectiveness, dosages, possible side effects as well as independent science based reviews of over 60  ingredients for gaining muscle mass we recommend the well respected Will Brink’s supplement review module found in his complete BodyBuilding Revealed program.

Visit this site for further details:

www.Bodybuildingrevealed.com/ingredients

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Branch chain amino acids (BCAA)

February 19, 2009 by About Supplements  
Filed under Body Building Supplements

BCAA’s

What is it?

In the world of amino acids, the structural “building blocks” of proteins, there are several classes and types of aminos. For example, we have the essential amino acids, the non-essential amino acids, the conditionally essential amino acids, and the branch chain amino acids (BCAA).

The essential amino acids are deemed as such because the body cannot manufacture them and they must be supplied by the diet. The non-essential amino acids can be made from the essential amino acids, and thus don’t have to be supplied by the diet for survival, though many non-essential amino acids play essential roles in health and metabolism in their own right.

What is it supposed to do?

The conditionally essential amino acids, so named because during certain periods, such as infancy or certain metabolic states, can be considered essential for that period of time. The branch chain amino acids (so named because they branch off another chain of atoms rather than form a straight line as other amino acids do) are leucine, valine and iso-leucine.

The BCAA’s are the amino acids that are primarily used (oxidized) during exercise and make up to one third of the amino acids in muscle tissue. It has been known for a long time that BCAA’s play a critical role in the turn over of lean body tissues (muscle) and is muscle sparing (i.e. anti-catabolic) in a variety of muscles wasting states. Of the three BCAA, L-leucine appears to be the most important to preserve hard earned muscle mass; intense exercise and certain disease states have been shown to eat up a great deal of L-leucine.

For more detailed information, including effectiveness, dosages, possible side effects as well as independent science based reviews of over 60  ingredients for gaining muscle mass we recommend the well respected Will Brink’s supplement review module found in his complete BodyBuilding Revealed program.

Visit this site for further details:

www.Bodybuildingrevealed.com/ingredients

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Arachidonic acid

February 19, 2009 by About Supplements  
Filed under Body Building Supplements

Arachidonic acid

What is it?

Arachidonic acid (AA) is a naturally occurring polyunsaturated fat, belonging to the Omega-6 family of fatty acids and is found in cell membrane phospholipids. It’s formed in the human body from the essential fatty acid Linoleic Acid (LA) or ingested pre-formed in various foods, with highest amounts found in red meat, egg yolks, and other animals based foods. From AA, highly unsaturated biologically active compounds such as prostaglandins, prostacyclin (PGI12), leukotrienes, and thromboxanes are formed.

What is it supposed to do?

The metabolism of AA is extremely complicated and far beyond the scope of this section. The many biologically active downstream metabolites of AA mentioned above are still under investigation with new roles for each being discovered all the time. Relating to the issue that concerns the reader (e.g., effects on strength, performance, and body composition), AA plays a role in the inflammatory response which appears to have direct effects on protein synthesis. In particular, the prostaglandin PGF2alpha has been identified as an important mediator of protein synthesis. In theory, an increase in the tissue levels of PGF2alpha (via ingestion of AA) might alter the anabolic to catabolic balance which would increase muscle mass. Other lines of evidence that support AA metabolites as being essential for protein synthesis come from studies that found the cox-1 enzyme inhibitors ibuprofen and acetaminophen greatly diminish the anabolic response to resistance exercise by inhibiting the normal post-exercise increase in levels of PGF2alpha. As these OTC drugs exhibit their anti-inflammatory actions by inhibiting the synthesis of prostaglandins, and it’s been found they reduce protein synthetic rates in response to weight training, it’s been seen as additional support for the concept that prostaglandins play an essential role in the anabolic response to exercise. Again, that’s a generalization of an extremely complicated system. The essential take home of the above is, prostaglandins are derived from dietary and in vivo conversion of AA and appear up-regulate recovery mechanisms including: inflammation and protein synthesis within skeletal muscle in response to resistance training.

For more detailed information, including effectiveness, dosages, possible side effects as well as independent science based reviews of over 60  ingredients for gaining muscle mass we recommend the well respected Will Brink’s supplement review module found in his complete BodyBuilding Revealed program.

Visit this site for further details:

www.Bodybuildingrevealed.com/ingredients

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